Wheat contamination with mycotoxins caused by Fusarium is of great economic importance. The current routine method of disease evaluation (single-location trial based on visual symptoms) does not yield the comprehensive data needed to accelerate breeding for resistance to Fusarium. We intend to lay the foundation for more efficient resistance breeding against Fusarium, by targeting deoxynivalenol (DON), the most important mycotoxin, and improve resistance to DON accumulation by genomic selection (GS).