Numéro du projet: 26.15.17.01.02_RumiSafe

RumiSafe: Renforcement de la sécurité des systèmes de production pour les ruminants face aux risques chimiques

Although preventive measures have historically reduced emissions into the environment and bioaccumulation in the animal feed and food chains of some legacy persistent organic pollutants (POPs like PCBs, dioxins…), new threats constantly emerge (PFAS, chlorinated paraffins…). To ensure the chemical safety of meat and milk from ruminants, it is imperative to understand and quantify the exposure and transfer (absorption, distribution, metabolism and excretion: ADME) of POPs in ruminant species. RumiSafe aims to

  1. characterize the route of POP exposure for ruminants,
  2. establish a proof of concept about da fast, thrifty and ethically responsible (3R-compliant) methodological framework for risk assessment embracing in vitro toxicokinetic data into physiologically based toxicokinetic (PBTK) models,
  3. provide innovative strategies and tools for risk monitoring, risk management, and land remediation, for legacy and emerging POPs.

RumiSafe will contribute to the long-term renovation of the methodology for the assessment and management of risks of on-farm POP contamination of livestock and sustain the continuous improvement of feed and food of animal origin safety.

Nom, Prénom Site
Dohme-Meier Frigga Posieux
Lerch Sylvain Posieux
Manzocchi Elisa Posieux
Silacci Paolo Posieux

Tiercin A., Albechaalany J., Driesen C., Schmidely P., Ortigues-Marty I., Zennegg M., Sauvant D., Loncke C., Lerch S.
BeefPOP: A physiologically based toxicokinetic model describing the fate of polychlorinated biphenyls in growing beef cattle.
Zenodo, Model, 2026

Przygoda L., Just H., Lerch S., Moenning J.L., Kowalczyk J., Numata J., Pieper R.
Physiologically-based toxicokinetic model of the transfer of branched and linear perfluoroalkyl acids in dairy goats.
Dans: 11th German Pharm-Tox Summit 2026. 17 March, Ed. Heinrich Heine University Düsseldorf, Düsseldorf (DE). 2026, S8.

Przygoda L., Just H., Lerch S., Moenning J.L., Kowalczyk J., Numata J.
Physiologically-based toxicokinetic model of the transfer of branched and linear perfluoroalkyl acids in dairy goats.
Dans: 11th German Pharm-Tox Summit 2026. 17 March, Ed. Heinrich Heine University Düsseldorf, Düsseldorf (DE). 2026.

Lerch S.
Toxicokinetic experiments to understand and quantify the transfer of pollutants in farm animals.
Dans: Catalyse Day 2026. 9 June, Ed. Agroscope, Posieux (CH). 2026.

Lerch S., Manzocchi E.
Exposure, transfer and depuration of PFAS in farm animals: Current state and gaps in knowledge.
Dans: BLV Fachtagung PFAS. 30 April, Ed. BLV, Online. 2026.

Lerch S., Moenning J.L., Przygoda L., Pieper R., Numata J.
Update and progress on physiologically based toxicokinetic modelling of the transfer of PFAS to growing lambs.
Dans: 93. «Carry Over» Sitzung. 12 May, Ed. BMLEH and MRI, Kulmbach (DE). 2026.

Moriceau M.A., Kowalczyk J., Larcher T., Raemy M., Karanikolopoulos G., Le Bizec B., Dervilly G., Lerch S., Cariou R.
Distribution homogeneity of environmental contaminants throughout (sub)liver parts.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 15 September, Riva Del Garda (IT). 2026.

Moriceau M.A., Kowalczyk J., Larcher T., Raemy M., Karanikolopoulos G., Le Bizec B., Dervilly G., Lerch S., Cariou R.
Distribution homogeneity of environmental contaminants throughout (sub)liver parts.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 15 September, Riva Del Garda (IT). 2026, 477.

Lerch S., Ratel J., Siegenthaler R., Dohme-Meier F., Engel E., Zennegg M.
Non-invasive biomonitoring of polychlorinated dibenzo-p-dioxin and dibenzofuran level in ewes from wool and cerumen target or volatile organic compound analyses.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 16 September, Riva Del Garda (IT). 2026.

Lerch S., Ratel J., Siegenthaler R., Dohme-Meier F., Engel E., Zennegg M.
Non-invasive biomonitoring of polychlorinated dibenzo-p-dioxin and dibenzofuran level in ewes from wool and cerumen target or volatile organic compound analyses.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 16 September, Riva Del Garda (IT). 2026, 192.

Tiercin A., Siegenthaler R., Zennegg M., Dohme-Meier F., Klevenhusen F., Numata J., Lerch S.
From soil contamination to food safety management: Physiologically based toxicokinetic modelling to predict PCDD/F transfer in beef production systems.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 16 September, Riva Del Garda (IT). 2026, 179.

Tiercin A., Siegenthaler R., Zennegg M., Dohme-Meier F., Klevenhusen F., Numata J., Lerch S.
From soil contamination to food safety management: physiologically based toxicokinetic modelling to predict PCDD/F transfer in beef production systems.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 13 September, Riva Del Garda (IT). 2026.

Lerch S., Przygoda L., Moenning J.L., Asshoff N., Stahl T., Krause T., Lamp J., Knappstein K., Albert C., Pieper R., Numata J.
A physiologically-based toxicokinetic model of the fate of perfluorooctansulfonic acid (PFOS) in growing lambs.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 15 September, Riva Del Garda (IT). 2026, 112.

Lerch S., Przygoda L., Moenning J.L., Ashoff N., Stahl T., Lamp J., Knappstein K., Albert C., Pieper R., Numata J.
A physiologically-based toxicokinetic model of the fate of perfluorooctansulfonic acid (PFOS) in growing lambs.
Dans: 46th International Symposium on POPs and Related Pollutants - Dioxin 2026. 13 September, Riva Del Garda (IT). 2026.

Tiercin A., Albachaalany J., Driesen C., Schmidely P., Ortigues-Marty I., Zennegg M., Sauvant D., Loncke C., Lerch S.
BeefPOP: a physiologically based toxicokinetic model describing the fate of polychlorinated biphenyls in growing beef cattle.
Environment International, 210, 2026, Article 110193.

Lerch S., Manzocchi E.
Esposizione, trasferimento e depurazione dei PFAS nei bovini da latte: Stato attuale e lacune nelle conoscenze.
Dans: Giornata cantonale del latte. 2 marzo, Ed. Ufficio della consulenza agricola, Sezione dell'agricoltura, Repubblica e Cantone Ticino, Cugnasco-Gerra (CH). 2026.

Lerch S., Moenning J.L., Przygoda L., Pieper R., Numata J.
Physiologically based toxicokinetic modelling of the transfer of PFAS to growing lambs.
Dans: 92. «Carry Over» Sitzung. 13 November, Ed. BMLEH, Online. 2025.

Lerch S.
Modélisation mécanistique du transfert des polluants éternels chez la vache laitière.
Dans: Agroscope Milchtagung. 27 novembre, Ed. Agroscope, Liebefeld (CH). 2025.

Tiercin A., Lerch S.
BeefPOP : Un modèle pour simuler et prévenir la contamination de la viande bovine par les polluants organiques persistants en élevage.
Dans: Netzwerk Nutztiere / Réseau animaux de rente. 7 novembre, Ed. HAFL, Zollikofen (CH). 2025.

Lerch S., Bucheli T.
Agroscope’s holistic approach to assess the fate of forever chemicals from soil to fork.
Dans: Empa PFAS Stakeholder-Event,. 27 October, Ed. Empa, Dübendorf (CH). 2025.