Invasive plants in agroecosystems (IPAs), including weeds and introduced neophytes, disrupt farming by lowering yields, damaging infrastructure, reducing forage quality, threatening livestock, and raising management costs. Control is complicated by herbicide resistance, regulatory limits, and climate change, which boosts IPA spread and competitiveness. Aligned with Swiss agroecosystem realities and Switzerland’s Crop Protection Strategy 2035 (FOAG, 2025), this project takes a four-part approach. First, identify harmful species and predict their spread using top-down and bottom-up methods. Second, study biology and distribution of case studies to understand reproduction and adaptation in Swiss systems. These steps provide the basis for targeted, sustainable management. Third, design and test preventive and curative strategies combining chemical, mechanical, biological, and agroecological methods. Finally, ensure dissemination and practical application of results to both policymakers and farmers (Communication). The project aims to build resilient, biodiverse, low-pesticide systems that secure production, ecosystem services, and long-term protection from IPAs.