Project number: 22.05.16.04.01

Engineering of New Bio-Based Molecules as Alternatives to Pesticides

Natural products (NPs) have been the starting point for the development of active biomolecules against pests and diseases. Bioactive NPs are obtained by bioassay-guided fractionation of an active extract from plants or microorganisms. Due to the challenges and technical difficulties associated with their production, industry moved away from NPs discovery and embraced new technologies, particularly combinatorial chemistry. However, new natural active compounds, with low impact on health and environment, are urgently needed. In this innovative project, fungi, plants and biogas digestate will be screened to identify bioactive NPs with new scaffolds. Bio-transformation and biotechnological approaches will be developed to generate new fungicides, nematicides, bactericides, and virucides.

Last Name, First Name Location
Ahrens Christian Reckenholz
Brabant Cécile Changins
Dahlin Paul Wädenswil
Dubuis Pierre-Henri Changins
Freimoser Florian Changins
Gindro Katia Changins
Hilber Maja Wädenswil
Ruthes Andrea Caroline Wädenswil
Schnée Sylvain Changins
Stucky Tobias Wädenswil

Huber R., Marcourt L., Félix F., Tardy S., Michellod E., Scapozza L., Wolfender J.-L., Gindro K., Queiroz E.F.
Study of phenoxy radical couplings using the enzymatic secretome of Botrytis cinerea.
Frontiers in Chemistry, 12, 2024, 1-15.

Zuffa S., Schmid R., Bauermeister A., Gomes P. W. P., Caraballo-Rodriguez A. M., El Abiead Y., Aron A. T., Gentry E. C., Zemlin J., Gindro K., Massana Codina J., Dorrestein P.
microbeMASST: A taxonomically informed mass spectrometry search tool for microbial metabolomics data.
Nature Microbiology, 9, 2024, 336-345.

Buyck B., Hofstetter V., Horak E., Cooper J., Bougher N.
The search for Australian relatives of the eucalypt-associated Russula prolifica (Russulales) from Madagascar reveals new Oceanian taxa in subsection Auratinae.
Australian Journal of Taxonomy, 47, 2023, 1-25.

Pellissier L., Gaudry A., Vilette S., Lecoultre N., Rutz A., Allard P.-M., Marcourt L., Queiroz E. F., Chave J., Eparvier V., Stien D., Gindro K., Wolfender J.-L.
Comparative metabolomic study of fungal foliar endophytes and their long-lived host Astrocaryum sciophilum: A model for exploring the chemodiversity of host-microbe interactions.
Frontiers in Plant Science, 14, 2023, 1-22.

Grillon A. C., Gindro K., Chevalley C., Massana Codina J.
Antifungal evaluation of plant extracts as alternative fungicides for the management of early and late blight in potato crops.
In: European Association for Potato Research EAPR Pathology and Pests Section Meeting. 4 September, Arras. 2023, 1.

Schürch Gabus S., Gindro K., Schnée S., Dubuis P.-H., Massana Codina J., Wilhelm M., Riat A., Lamoth F., Sanglard D.
Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.
Medical Mycology, Preprint, 2023, 1-25.

Vigneron N., Grimplet J., Remolif E., Rienth M.
Unravelling molecular mechanisms involved in resistance priming against downy mildew (Plasmopara viticola) in grapevine (Vitis vinifera L.).
Scientific Reports, 13, 2023, 1-13.

Alfattani A., Queiroz E. F., Marcourt L., Leoni S., Stien D., Hofstetter V., Gindro K., Perron K., Wolfender J.-L.
One-step bio-guided isolation of secondary metabolites from the endophytic fungus Penicillium crustosum using high-resolution semi-preparative HPLC.
Combinatorial Chemistry & High Throughput Screening, In Press, 2023, 1-10.

Huber R., Marcourt L., Héritier M., Luscher A., Guebey L., Schnée S., Michellod E., Guerrier S., Wolfender J-L., Scapozza L., Köhler T., Gindro K., Queiroz E. F.
Generation of potent antibacterial compounds through enzymatic and chemical modifications of the trans-delta-viniferin scafold.
Scientific Reports, 13, (15986), 2023, 1-21.

Stucky T., Hochstrasser M., Meyer S., Segessemann T., Ruthes A. C., Ahrens C., Pelludat C., Dahlin P.
A novel robust screening assay identifies pseudomonas strains as reliable antagonists of the root-knot nematode Meloidogyne incognita.
Microorganisms, 11, (8), 2023, 1-16.

Zwygart A. C.-A., Medaglia C., Huber R., Poli R., Marcourt L., Schnée S., Michellod E., Mazel-Sanchez B., Constant S., Huang S., Bekliz M., Clément S., Gindro K., Ferreira Queiroz E., Tapparel C.
Antiviral properties of trans-δ-viniferin derivatives against enveloped viruses.
Biomedicine & Pharmacotherapy, 163, 2023, 1-11.

Oldani E., Cabianca A., Dahlin P., Ruthes A. C.
Biogas digestate as potential sorce for nematicides.
Environmental Technology & Innovation, 29, 2023, 1-14.

Rita de Souza C., Gindro K., Verdenal T., Spring J.-L., Spangenberg J.-E., Zufferey V.
Water deficit responses of field‑grown Pinot noir mediated by rootstock genotypes in a cool climate region.
OENO One, 56, (2), 2022, 136-148.

Zufferey V., Gindro K., Verdenal T., Murisier F., Viret O.
Anatomie et physiologie : Alimentation et carences, accidents physiologiques et climatiques.
AMTRA. La vigne (Vol. 4), 2022, 564 pp.

Monod V., Hofstetter V., Zufferey V., Viret O., Gindro K., Croll D.
Quantifying trade-offs in the choice of ribosomal barcoding markers for fungal amplicon sequencing: A case study on the grapevine trunk mycobiome.
Microbiology Spectrum, 10, (6), 2022, 1-13.

Gfeller A., Fuchsmann P., De Vrieze M., Gindro K., Weisskopf L.
Bacterial volatiles known to inhibit Phytophthora infestans are emitted on potato leaves by Pseudomonas strains.
Microorganisms, 10, (8), 2022, 1-11.

Dubey S., Pellaud S., Gindro K., Schuerch J., Golay J., Gloor R., Ghali K., Dubey O.
Fungal Infection in free-ranging snakes caused by opportunistic species.
Emerging Animal Species, 3, (May), 2022, 1-4.

Girelli C. R., Hussain M., Verweire D., Oehl M. C., Massana Codina J., Avendano M. S., Migoni D., Scortichini M., Fanizzi F. P.
Agro-active endo-therapy treated Xylella fastidiosa subsp. pauca-infected olive trees assessed by the first 1H-NMR-based metabolomic study.
Scientific Reports, 12, 2022, 1-13.

Huber R., Marcourt L., Quiros L., Luscher A., Schnée S., Michellod E., Ducret V., Kohler T., Perron K., Wolfender JL., Gindro K., Ferreira Queiroz E.
Chiral separation of stilbene dimers generated by biotransformation for absolute configuration determination and antibacterial evaluation.
Frontiers in Chemistry, 10, 2022, 1-11.

Gindro K., Schnée S., Lecoultre N., Michellod E., Zufferey V., Spring J.-L., Viret O., Dubuis P.-H.
Development of downy mildew in grape bunches of susceptible and resistant cultivars: infection pathways and limited systemic spread: Downy mildew development in grape bunches.
Australian Journal of Grape and Wine Research, 2022, 1-9.

Huber R., Koval A., Marcourt L., Héritier M., Schnée S., Michellod E., Scapozza L., Katanaev V., Wolfender JL., Gindro K., Queiroz EF.
Chemoenzymatic Synthesis of Original Stilbene Dimers Possessing Wnt Inhibition Activity in Triple-Negative Breast Cancer Cells Using the Enzymatic Secretome of Botrytis cinerea Pers.
Frontiers in Chemistry, 10, (881298), 2022, 1-32.

Dessilly G., Pâques AT., Vandenbroucke AT., Hazée P., Gaume A., Gindro K., Schnée S., Lakaye F., Kabamba-Mukadi B.
In vitro evaluation of virucidal activity of disodium citrate perhydrate (2SCP) disinfectant against SARS-CoV-2 virus.
Journal of Global Antimicrobial Resistance, 28, 2022, 158-160.

Huber R., Marcourt L., Koval A., Schnée S., Righi D., Michellod E., Katanaev V., Wolfender JL., Gindro K., Queiroz E.
Chemoenzymatic synthesis of complex phenylpropanoid derivatives by the Botrytis cinerea secretome and evaluation of their Wnt inhibition activity.
Frontiers in Plant Science, 12, 2022, 1-19.