Polychlorinated biphenyls (PCBs) are highly persistent organic pollutants (POPs) that are still of concern, although they have been banned in Switzerland since 1986. Besides being toxic to humans and the environment, PCBs are easily dispersed in the environment, are highly hydrophobic and bioaccumulate in the food chain. Therefore, the main PCB exposure route for humans is the consumption of food of animal origin that accounts in Switzerland for more than 90% of the overall human exposure, of which 70% is from bovine meat and dairy products [1]. Apart from potential long-term adverse health effects, elevated PCB levels in animal products may also lead to loss of the livestock at the expense of the farmer. To address this problem, the aims are i) the identification of a potential PCB entry pathway into food products, as well as ii) the assessment of the toxicokinetics of PCBs to improve risk management. Therefore, an in vivo experiment is currently conducted, in which mother cows are orally exposed over a long time period to a soil-grass silage mixture containing PCB levels close to the feed maximum regulatory limit, while feeding their calves through milk. These experimental data will be used to assess the predictive ability of a dynamic model that incorporates the soil uptake from grazing and the PCB transfer from the mother cows to their calf [2]. The combination of in vivo and in silico will help to better understand the accumulation process of PCBs in cattle and, on this basis, to derive recommendations to further mitigate PCB levels and improve food safety.